|
rs2066844
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Within defined statistical parameters, we excluded a role for the CARD15 1007fs and R702W variants in RA susceptibility.
|
12595627 |
2003 |
|
rs6920220
|
|
|
0.900 |
GeneticVariation |
BEFREE |
With the exception of rs6920220, which shows highly consistent results, other proposed markers have high between-study heterogeneity that may reflect unrecognised phenotypic or genetic variability (eg, gene environment interactions) within rheumatoid arthritis.
|
19401279 |
2010 |
|
rs763780
|
|
|
0.060 |
GeneticVariation |
BEFREE |
With respect to IL-17F rs763780, the C versus T allele (OR = 1.94; P = 0.040), the TC versus TT (OR = 1.39; P = 0.041), the CC versus TT (OR = 2.71; P = 0.003), as well as the TC + CC versus TT genotype (OR = 1.83; P = 0.032) were risk factors for RA.
|
28186427 |
2017 |
|
rs2259571
|
|
|
0.020 |
GeneticVariation |
BEFREE |
With regard to the AIF1 rs2259571 polymorphism the remission of RA symptoms was observed in 52.99% of AA genotype carriers, in 45.25% of subjects with AC genotype, and in 32.84% with CC.
|
24018427 |
2013 |
|
rs2274976
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While rs1801131A/C genetic polymorphism is associated with the clinical response, rs1801133C/T and rs2274976A/G genetic polymorphisms are associated with MTX-related AEs in the treatment of RA.
|
20863444 |
2010 |
|
rs1801133
|
|
|
0.050 |
GeneticVariation |
BEFREE |
While rs1801131A/C genetic polymorphism is associated with the clinical response, rs1801133C/T and rs2274976A/G genetic polymorphisms are associated with MTX-related AEs in the treatment of RA.
|
20863444 |
2010 |
|
rs1801131
|
|
|
0.030 |
GeneticVariation |
BEFREE |
While rs1801131A/C genetic polymorphism is associated with the clinical response, rs1801133C/T and rs2274976A/G genetic polymorphisms are associated with MTX-related AEs in the treatment of RA.
|
20863444 |
2010 |
|
rs540386
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Whereas TRAF6 rs540386 was not associated with RA susceptibility, it was however found to be a risk factor for reduced lumbar spine Z-score in the recessive model (OR = 3.34, 95% CI = (1.01-11.00), p = 0.038).
|
30506403 |
2019 |
|
rs729302
|
|
|
0.030 |
GeneticVariation |
BEFREE |
When the patients were stratified by the SE, the rs729302</span> A allele was found to confer increased risk to RA</span> in patients that were SE negative (OR 1.50, 95% CI 1.17 to 1.92, p = 0.001) as compared with patients carrying the SE (OR 1.11, 95% CI 0.93 to 1.33, p = 0.24).
|
18408250 |
2009 |
|
rs10484554
|
|
|
0.710 |
GeneticVariation |
BEFREE |
When the HLA-C rs10484554 CC homozygote genotype was used as the reference group, the TT/CT genotypes were associated with a significantly decreased risk for RA (adjusted OR = 0.72, 95% CI = 0.52-0.99, p = 0.044).
|
24566686 |
2014 |
|
rs6822844
|
|
|
0.770 |
GeneticVariation |
BEFREE |
When combined in a meta-analysis using data from a total of 9,772 cases and 10,909 controls there was a genome-wide level of significance supporting association of rs6822844 with RA (OR=0.86 (0.82 to 0.91), P=8.8x10(-8), P=2.1x10(-8) including North American Rheumatoid Arthritis Consortium data).
|
20553587 |
2010 |
|
rs12566340
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We, therefore, tested rs12566340 for association with RA conditional on rs2476601; there was no evidence for an independent effect at rs12566340 (P = 0.76).
|
20975833 |
2010 |
|
rs6822844
|
|
|
0.770 |
GeneticVariation |
BEFREE |
We tested SNP rs6822844 for association with disease in 350 T1D-affected and 1,047 rheumatoid arthritis (RA)-affected Dutch patients and in 929 controls.
|
17999365 |
2007 |
|
rs909685
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We successfully identified two SNPs, rs1893592 in UBASH3A and rs909685 in SYNGR1, as significantly associated with the disease status of RA using our two-stage strategy.
|
29262569 |
2017 |
|
rs1893592
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We successfully identified two SNPs, rs1893592 in UBASH3A and rs909685 in SYNGR1, as significantly associated with the disease status of RA using our two-stage strategy.
|
29262569 |
2017 |
|
rs911263
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We successfully identified a common variant, rs911263, as being significantly associated with the disease status of RA (P = 4.8 × 10<sup>-5</sup>, OR = 0.64).
|
28361912 |
2017 |
|
rs959728
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We study the association between three protein kinase C, eta gene polymorphisms (+8134C/T, rs912620, rs959728), and susceptibility to rheumatoid arthritis.
|
17957454 |
2008 |
|
rs912620
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We study the association between three protein kinase C, eta gene polymorphisms (+8134C/T, rs912620, rs959728), and susceptibility to rheumatoid arthritis.
|
17957454 |
2008 |
|
rs3087243
|
|
|
0.850 |
GeneticVariation |
BEFREE |
We studied RA risk associated with PTPN22 (rs2476601), PADI-4 (rs2240340), and CTLA-4 (rs3087243) in the Nurses' Health Study (NHS) and NHSII.
|
18462498 |
2008 |
|
rs2240340
|
|
|
0.770 |
GeneticVariation |
BEFREE |
We studied RA risk associated with PTPN22 (rs2476601), PADI-4 (rs2240340), and CTLA-4 (rs3087243) in the Nurses' Health Study (NHS) and NHSII.
|
18462498 |
2008 |
|
rs2476601
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We studied RA risk associated with PTPN22 (rs2476601), PADI-4 (rs2240340), and CTLA-4 (rs3087243) in the Nurses' Health Study (NHS) and NHSII.
|
18462498 |
2008 |
|
rs2240017
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed that the g.-1514T>C and c.99C>G polymorphisms are suggestively associated with RA susceptibility.
|
19287198 |
2009 |
|
rs6933349
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We showed that DNA methylation of cg21325723 can mediate the gene-environment interaction between rs6933349 and smoking, impacting the risk of developing ACPA-positive RA, thus being a potential regulator that integrates both internal genetic and external environmental risk factors.
|
28356135 |
2017 |
|
rs2929973
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed that RA disease was more likely with the AA genotype compared with the AG genotype of SNP rs2977537 (adjusted odds ratio [AOR]: 0.54; 95% confidence interval [CI]: 0.34-0.84), and with the TT genotype (AOR: 0.24; 95% CI: 0.13-0.39) or the GG genotype (AOR: 0.05; 95% CI: 0.03-0.10) compared with the GT genotype of rs2929973, and with the AA genotype (AOR: 0.34; 95% CI: 0.22-0.54) or GG genotype (AOR: 0.52; 95% CI: 0.31 to 0.87) vs the AG genotype of rs2977530.
|
31689765 |
2019 |
|
rs2977530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed that RA disease was more likely with the AA genotype compared with the AG genotype of SNP rs2977537 (adjusted odds ratio [AOR]: 0.54; 95% confidence interval [CI]: 0.34-0.84), and with the TT genotype (AOR: 0.24; 95% CI: 0.13-0.39) or the GG genotype (AOR: 0.05; 95% CI: 0.03-0.10) compared with the GT genotype of rs2929973, and with the AA genotype (AOR: 0.34; 95% CI: 0.22-0.54) or GG genotype (AOR: 0.52; 95% CI: 0.31 to 0.87) vs the AG genotype of rs2977530.
|
31689765 |
2019 |